Join 4Dcell and become part of a pioneering French biotech on a mission to transform drug discovery and toxicology. We’re engineers and biologists united by a single goal: to replace animal testing with intelligent, in vitro “organ-in-a-well” models that deliver unprecedented predictive power to drive tomorrow’s therapies.
4Dcell has developed two flagship solutions: the SmartHeart™ Platform, which recreates human ventricular tissue in a standard 96-well plate, and the first-in-class SmartSphero™ Technology, enabling the generation of a wide range of organoids.
You’ll collaborate with leading biophysicists, engineers, and biologists to tackle the toughest health challenges, from heart failure and immuno-oncology to pancreas and renal diseases. We combine ambition with a supportive, curiosity-driven culture.
Why intern with us?
- Freedom and responsibility to structure and lead your own projects
- Hands-on exposure to game-changing technologies
- A team that values collaboration, growth, and fun
- Membership in a high-energy, fast-growing team developing truly game-changing, high-tech products
- The opportunity to navigate both a commercial start-up environment and an R&D scientific setting
- Close collaboration with experts in technology, marketing, sales, application science and operations
- Step into a role where your work accelerates drug discovery, improves patient outcomes, and builds a more ethical pharmaceutical future.
Context
4Dcell has developed a platform to produce 3D ring-shaped organoids https://www.4dcell.com/heart-3d . The cells self-assemble in a contractile ring around a deformable central pillar. To assess the contraction of the tissues, a software based on image segmentation was developed to track the inner and outer rings of the tissues. You will contribute to the continued development and optimization of SmartX 2.0, focusing on improving segmentation accuracy, analysis speed, and expanding its capabilities. This is a high-impact internship, directly supporting the advancement of 3D cardiac tissue modeling.
Main Responsibilities
· Software Optimization:
Enhance the precision and performance of the contraction analysis pipeline through systematic parameter tuning, advanced image preprocessing, and refined signal processing techniques. Retrain and fine-tune image segmentation models on curated datasets of organoid ring imagery.
· Software Adaptation to New SmartHeart Design:
Retrain the analysis software to support the updated SmartHeart hardware design, including adaptation of the analysis logic and ring identification algorithms.
· UX & Performance Enhancements:
Redesign key components of the SmartX 2.0 user interface and back-end architecture to improve usability, scalability, and processing speed.
· Post-Processing Pipeline Integration:
Conceptualize and architect a post-processing pipeline tailored to client-specific analytical requirements.
· Industry Workflow Compliance & Integration:
Ensure software outputs conform to the data standards and IT workflows of pharmaceutical industry environments.
Candidate Profile
· Master’s student in Engineering with a specialization in Software Engineering, Deep learning, or related field. OR Master’s student in Software Engineering with knowledge in biology
· Solid programming skills in Python
· Experience with image processing, segmentation and machine learning libraries.
· Interest in biomedical applications.
· Strong autonomy
· Strong communication and listening skills: interactions with internal and external collaborators, to adapt the software to the clients’ needs
· Bonus: Experience with GUI development (e.g., PyQt, Tkinter) and bioimaging tools (ImageJ/Fiji, CellProfiler). Experience in signal processing appreciated.
Duration & Terms
- 6-month internship, starting October 2026
- Based in Montreuil, with partial remote work possible
- Legal internship stipend + partial transport reimbursement
Rémunération : 650,00€ à 700,00€ par mois
Lieu du poste : En présentiel
