Oxygen Tension: A Key Driver of Neural Stem Cell Fate in Brain Development and Repair
Project: This project will be conducted in close collaboration with the team of Boris Egger at University of Fribourg (CH).
It investigates how oxygen availability regulates neural stem cell (NSC) behavior during brain development and repair. NSCs can either remain quiescent or become activated to generate new neural cells, and this balance is essential for lifelong brain maintenance. Using complementary mouse and Drosophila models, the project will examine how changes in oxygen tension influence NSC activation, gene expression, and cell fate. Building on previous work showing that low oxygen can reactivate quiescent NSCs, the student will combine oxygen biosensors, genetic approaches, and single-cell transcriptomics to address three aims: determine how oxygen controls NSC activation, identify the underlying molecular mechanisms, and assess how oxygen shapes the types of neural cells produced.
This project will provide new insight into how local oxygen environments regulate brain development to identify mechanisms relevant to neural repair.
Environment: You will join a multidisciplinary team of scientists at the Lyon Neuroscience Center (CRNL). The CRNL benefits from state-of-the-art research platforms, and provide a high-quality scientific, technological and medical environment.
Contract Duration: 2.5 years
Candidates: We are looking for an enthusiastic and highly motivated scientist with a PhD in neuroscience, biomedicine, biotechnology, or a related field, and a strong interest in neural stem cells, advanced imaging, and analytical approaches. Candidates should have a solid scientific track record demonstrated by publications, experience working with mice and performing microsurgery, and strong laboratory skills combined with scientific rigor and a high degree of independence. Excellent communication skills, proficiency in English, a collaborative mindset, and a willingness to mentor junior team members are expected. Experience in neural stem cell biology, vascularization, and/or brain development would be an advantage, as would prior experience with in utero electroporation and proficiency in Python and/or R.
Type d'emploi : Temps plein
Rémunération : 35 000,00€ à 40 000,00€ par an
Avantages :
- Flextime
- Prise en charge du transport quotidien
Formation:
- Bac +8 (Doctorat) (Requis)
Langue:
Lieu du poste : En présentiel
